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KMID : 0387420120230010129
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Korean Society of Oriental Neuropsychiatry
2012 Volume.23 No. 1 p.129 ~ p.143
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Neuroprotective effects of Sohaphwangwon essential oil in a Parkinson’s disease mouse model
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Kim In-Ja
Lee Ji-Hyun
Song Kyoo-Ju
Koo Byung-Su
Kim Geun-Woo
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Abstract
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Objectives: To evaluate the neuroprotective effects of the essential oil from Sohaphwangwon (SH), a Chinese traditional medicinal prescription in a Parkinson’s disease mouse model.
Methods: 1. The neuroprotective effect of SH on primary neuronal cells was examined by using 1-methyl-4-phenylpyridinium ion (MPP+). 2. The neuroprotective effect of SH was examined in a Parkinson’s disease mouse model. C57BL/6 mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg/day), intraperitoneal (i.p.) for 5 days. SH inhalation was applied before MPTP treatment for 7 days and continued until 12 days after the first MPTP treatment. 3. To find out the intracellular target signal molecule(s) regarding the neuroprotective effect of SH essential oil, brain-derived neurotropic factor (BDNF) and synaptic protein SNAP25 were examined by Western blot analysis.
Results: 1. MPP+ induced a concentration-dependent decrease in cell viability. However, in the presence of 3 and 5 ug/ml of SH, MPP+-induced cell death was significantly reduced. 2. SH inhalation in MPTP mice led to the restoration of behavioral impairment and rescued tyrosine hydroxylase (TH)-positive dopaminergic neurodegeneration. 3. In SH / MPTP mice, BDNF and SNAP25 increased.
Conclusions: This experiment suggests that the neuroprotective effect of SH essential oil is mediated by the expression of BDNF. Furthermore, SH essential oil may serve as a potential preventive or therapeutic agent regarding Parkinson’s disease.
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KEYWORD
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Sohaphwangwon, Parkinson’s disease, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)
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